问个 MySql 优化问题， 16G， 8 核服务器

服务器配置：
处理器：Xeon E3-1230 V2
内存：16G DDR3 1600Mhz
硬盘：1TB 企业级硬盘

我现在的配置
[mysqld]
port = xxxx
socket = xxx
datadir = xxxx
default_storage_engine = MyISAM
#skip-external-locking
#loose-skip-innodb
key_buffer_size = 2048M
max_allowed_packet = 100G
table_open_cache = 1024
sort_buffer_size = 4M
net_buffer_length = 4K
read_buffer_size = 4M
read_rnd_buffer_size = 256K
myisam_sort_buffer_size = 64M
thread_cache_size = 128
query_cache_size = 128M
tmp_table_size = 128M

#skip-networking
#skip-name-resolve
max_connections = 3000
max_connect_errors = 600
open_files_limit = 65535

log-bin=mysql-bin
binlog_format=mixed
server-id = 1
expire_logs_days = 10

default_storage_engine = InnoDB
innodb_data_home_dir = xxxxx
innodb_data_file_path = ibdata1:10M:autoextend
innodb_log_group_home_dir =xxxxx
innodb_buffer_pool_size = 1024M
innodb_additional_mem_pool_size = 2M
innodb_log_file_size = 256M
innodb_log_buffer_size = 8M
innodb_flush_log_at_trx_commit = 1
innodb_lock_wait_timeout = 500

[mysqldump]
quick
max_allowed_packet = 16M

[mysql]
no-auto-rehash

[myisamchk]
key_buffer_size = 256M
sort_buffer_size = 4M
read_buffer = 2M
write_buffer = 2M

[mysqlhotcopy]
interactive-timeout

请问如何优化一下呢，数据库读写量大。